US 12,435,032 B2
L-γ-methyleneglutamine compounds and methods of use
Hoang Van Le, Oxford, MS (US); and Md. Imran Hossain, Vernon Hills, IL (US)
Assigned to University of Mississippi, University, MS (US)
Appl. No. 17/597,550
Filed by University of Mississippi, University, MS (US)
PCT Filed Jul. 13, 2020, PCT No. PCT/US2020/041839
§ 371(c)(1), (2) Date Jan. 11, 2022,
PCT Pub. No. WO2021/011492, PCT Pub. Date Jan. 21, 2021.
Claims priority of provisional application 62/873,586, filed on Jul. 12, 2019.
Prior Publication US 2022/0267255 A1, Aug. 25, 2022
Int. Cl. C07C 237/20 (2006.01); A61P 35/00 (2006.01)
CPC C07C 237/20 (2013.01) [A61P 35/00 (2018.01)] 15 Claims
 
1. A compound having a structure according to Formula I:

OG Complex Work Unit Chemistry
wherein R1 is NHR4;
R2 is H or an amine protecting group;
R3 is OH, or substituted or unsubstituted lower alkoxy; and
R4 is an alkyl group substituted with an aryl group or a heteroaryl group, substituted or unsubstituted aryl, substituted or unsubstituted hetaryl.