US 12,435,027 B1
Preparation method of N-butenyl amide compounds
Xingliang Nie, Jinhua (CN); Yuzhi Ma, Jinhua (CN); Jin Yan, Jinhua (CN); Dongbing Yang, Jinhua (CN); and Kexin Fang, Jinhua (CN)
Assigned to ZHEJIANG NORMAL UNIVERSITY, Jinhua (CN)
Filed by ZHEJIANG NORMAL UNIVERSITY, Jinhua (CN)
Filed on May 2, 2025, as Appl. No. 19/196,834.
Claims priority of application No. 202411708939.3 (CN), filed on Nov. 27, 2024.
Int. Cl. C07C 231/12 (2006.01); C07C 269/06 (2006.01); C07D 213/81 (2006.01); C07D 307/68 (2006.01); C07D 333/38 (2006.01)
CPC C07C 231/12 (2013.01) [C07C 269/06 (2013.01); C07D 213/81 (2013.01); C07D 307/68 (2013.01); C07D 333/38 (2013.01); C07C 2601/04 (2017.05); C07C 2601/14 (2017.05)] 4 Claims
 
1. A preparation method of N-butenyl amide compounds, wherein N-aryloxy amide and benzenesulfonyl substituted olefins are added into an alkaline organic solvent, a free radical initiator is added, and the N-butenyl amide compounds are prepared through a free radical amidation reaction of olefins under illumination;
wherein the free radical amidation reaction of the olefins is:

OG Complex Work Unit Chemistry
wherein R1 is selected from an alkyl group, substituted alkyl group, alkenyl group, ester group, aryl group, substituted aryl group, or heteroaromatic ring, R2 is hydrogen or aryl group, and R3 is CO2Et, and Ar is 4-nitrophenyl;
the organic solvent is N, N-dimethylacetamide;
the alkali is triethylamine; and
a wavelength of the illumination is 460 nm.