US 12,435,026 B2
Solabegron zwitterion and uses thereof
Raymond E. Stevens, West Chester, PA (US); Dalian Zhao, Fanwood, NJ (US); and Bingidimi Itute Mobele, Altamont, NY (US)
Assigned to B3AR THERAPEUTICS, INC., Palo Alto, CA (US)
Filed by B3AR THERAPEUTICS, INC., Palo Alto, CA (US)
Filed on May 18, 2023, as Appl. No. 18/199,205.
Application 16/018,945 is a division of application No. 15/332,956, filed on Oct. 24, 2016, granted, now 10,065,922, issued on Sep. 4, 2018.
Application 18/199,205 is a continuation of application No. 17/077,446, filed on Oct. 22, 2020, granted, now 11,691,944.
Application 17/077,446 is a continuation of application No. 16/246,114, filed on Jan. 11, 2019, granted, now 10,844,004, issued on Nov. 24, 2020.
Application 16/246,114 is a continuation of application No. 16/018,945, filed on Jun. 26, 2018, granted, now 10,221,126, issued on Mar. 5, 2019.
Claims priority of provisional application 62/245,656, filed on Oct. 23, 2015.
Claims priority of provisional application 62/245,670, filed on Oct. 23, 2015.
Claims priority of provisional application 62/345,327, filed on Jun. 3, 2016.
Claims priority of provisional application 62/345,357, filed on Jun. 3, 2016.
Claims priority of provisional application 62/345,574, filed on Jun. 3, 2016.
Prior Publication US 2024/0124391 A1, Apr. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 229/52 (2006.01); A61K 31/196 (2006.01); A61K 45/06 (2006.01); C07C 227/16 (2006.01); C07D 233/26 (2006.01); C07D 498/04 (2006.01)
CPC C07C 229/52 (2013.01) [A61K 31/196 (2013.01); A61K 45/06 (2013.01); C07C 227/16 (2013.01); C07D 233/26 (2013.01); C07D 498/04 (2013.01); C07B 2200/13 (2013.01)] 19 Claims
 
1. A solid compound according to Formula II:

OG Complex Work Unit Chemistry
wherein the compound is characterized by:
an x-ray powder diffraction pattern having peaks expressed in degrees 2θ at 17.6, 18.7, 19.6, 20.1, 20.5, 23.7, and 25.8; and
a differential scanning calorimetry (DSC) thermograph exhibiting a very broad peak at about 67° C., a broad peak at about 131° C., and a narrow peak at about 180° C.