US 12,434,217 B2
Device for continuously preparing 2,6-dihydroxybenzaldehyde
Hao Hong, Morrisville, NC (US); Jiangping Lu, Tianjin (CN); Xichun Feng, Tianjin (CN); Xin Zhang, Tianjin (CN); and Bo Yan, Tianjin (CN)
Assigned to ASYMCHEM LABORATORIES (FUXIN) CO., LTD., Liaoning (CN)
Appl. No. 17/642,194
Filed by ASYMCHEM LABORATORIES (FUXIN) CO., LTD., Liaoning (CN)
PCT Filed Sep. 12, 2019, PCT No. PCT/CN2019/105754
§ 371(c)(1), (2) Date Mar. 10, 2022,
PCT Pub. No. WO2021/046815, PCT Pub. Date Mar. 18, 2021.
Prior Publication US 2022/0297080 A1, Sep. 22, 2022
Int. Cl. B01J 19/18 (2006.01); B01J 19/24 (2006.01); C07C 41/54 (2006.01); C07C 45/50 (2006.01); C07C 45/64 (2006.01)
CPC B01J 19/1862 (2013.01) [B01J 19/1818 (2013.01); B01J 19/242 (2013.01); B01J 19/245 (2013.01); C07C 41/54 (2013.01); C07C 45/505 (2013.01); C07C 45/64 (2013.01); B01J 2219/00033 (2013.01); B01J 2219/00094 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device for continuously preparing 2,6-dihydroxybenzaldehyde, wherein the device comprises a first continuous reaction units, a second continuous reaction unit, and a third continuous reaction unit connected in series, the first continuous reaction units is used for hydroxy protection reaction, the second continuous reaction unit is used for lithiation and hydroformylation, and the third continuous reaction unit is used for deprotection reaction, wherein the third continuous reaction unit comprises:
a first columnar continuous reactor (32), connected to the second continuous reaction unit (20) and used for deprotection of the lithiated hydroformylated product while performing liquid separation to obtain an organic phase containing 2,6-dihydroxybenzaldehyde and an aqueous phase;
a deprotection agent supply device, the first columnar continuous reactor sets up a deprotection agent inlet and a lithiated hydroformylated product inlet, the deprotection agent supply device is connected to the deprotection agent inlet, the lithiated hydroformylated product inlet is connected to the second continuous reaction unit.