US 12,434,208 B2
Continuous processing system and methods for internal and external modifications to nanoparticles
Antonio P. Costa, Farmington, CT (US); and Diane J. Burgess, Farmington, CT (US)
Assigned to University of Connecticut, Farmington, CT (US)
Appl. No. 17/286,956
Filed by University of Connecticut, Farmington, CT (US)
PCT Filed Oct. 28, 2019, PCT No. PCT/US2019/058305
§ 371(c)(1), (2) Date Apr. 20, 2021,
PCT Pub. No. WO2020/087064, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/751,162, filed on Oct. 26, 2018.
Prior Publication US 2021/0379545 A1, Dec. 9, 2021
Int. Cl. B01F 33/3033 (2022.01); A61K 9/127 (2025.01); A61K 9/1271 (2025.01); A61K 9/1278 (2025.01); A61K 9/50 (2006.01); B01F 25/433 (2022.01); B01F 35/21 (2022.01); B01F 35/71 (2022.01); B01F 35/90 (2022.01); B01J 13/04 (2006.01); B82Y 5/00 (2011.01); B82Y 35/00 (2011.01); B82Y 40/00 (2011.01)
CPC B01F 33/3033 (2022.01) [A61K 9/1271 (2013.01); A61K 9/1278 (2013.01); B01F 25/433 (2022.01); B01F 35/2111 (2022.01); B01F 35/7176 (2022.01); B01F 2035/99 (2022.01); B82Y 5/00 (2013.01); B82Y 35/00 (2013.01); B82Y 40/00 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A system for internal and external modification of pre-formed nanoparticles in a continuous process, the system comprising:
a first inlet;
a second inlet;
a first pump in fluid communication with the first inlet;
a second pump in fluid communication with the second inlet;
a first flow meter in fluid communication with the first pump;
a second flow meter in fluid communication with the second pump;
a mixing chamber in fluid communication with the first flow meter and the second flow meter;
a first heat exchanger in fluid communication with the mixing chamber;
a first analyzer positioned downstream from the first heat exchanger, wherein the first analyzer is configured to measure a first attribute of a plurality of modified pre-formed nanoparticles;
a second analyzer positioned downstream from the first analyzer, wherein the second analyzer is configured to measure a second attribute of the plurality of modified pre-formed nanoparticles that is different than the first attribute; and
a controller configured to:
determine a difference between one or more desired attributes of the plurality of modified nanoparticles and one or more determined attributes of the plurality of modified nanoparticles; and
in response to the determined difference, adjust one or more parameters of the system.