	US 12,434,170 B2
	Method for preparing bioactive particles by spray drying, liquid nitrogen quick-freezing and vacuum freeze drying
Xiaodong Chen, Nantong (CN); Wenjie Lu, Nantong (CN); and Zhenkai Liao, Nantong (CN)
Assigned to NANTONG DONG-CONCEPT NEW MATERIAL TECHNOLOGY LTD., Nantong (CN)
Appl. No. 18/280,244
Filed by NANTONG DONG-CONCEPT NEW MATERIAL TECHNOLOGY LTD., Nantong (CN)
PCT Filed Jan. 20, 2022, PCT No. PCT/CN2022/072985 § 371(c)(1), (2) Date Sep. 4, 2023, PCT Pub. No. WO2023/103153, PCT Pub. Date Jun. 15, 2023.
Claims priority of application No. 202111512342.8 (CN), filed on Dec. 8, 2021.
Prior Publication US 2024/0139647 A1, May 2, 2024
Int. Cl. B01D 1/18 (2006.01); B01J 2/04 (2006.01); F26B 3/12 (2006.01)

CPC B01D 1/18 (2013.01) [B01J 2/04 (2013.01); F26B 3/12 (2013.01)]

7 Claims

1. A method for preparing dried bio-active particles by spraying-drying, liquid nitrogen quick-freezing, and vacuum freeze drying, characterized by comprising the following steps:

Step 1: preparing a feed liquid;

Step 2: preheating the inside of a spray tower, wherein the feed liquid enters the spray tower from the top of the spray tower through a pump, the feed liquid is atomized by an atomizer in the spray tower to form liquid droplets, dispersing air is introduced into the top of the spray tower, and the dispersing air disperses the atomized liquid droplets;

Step 3: introducing hot air into the top of the spray tower, wherein a temperature at the top of the spray tower is controlled at 80-120° C., and the liquid droplets are turned into dry-like particles after being dried by the hot air, wherein wherein 85-95% of the water content in the liquid droplets is removed by spray drying;

Step 4: collecting the dry-like particles from a bottom of the spray tower and transferring the dry-like particles to a cooling pool for quick freezing;

Step 5: without intermediate storage and while maintaining the frozen state transferring the frozen particles formed in Step 4 to a freeze drying device for freeze drying.