US 12,434,077 B2
Anti-tumor compound and preparation method and use thereof
Yu Zhang, Shanghai (CN); Zhongyuan Zhu, Shanghai (CN); Haiqing Hua, Shanghai (CN); Bing Li, Shanghai (CN); Jian Li, Shanghai (CN); Shengchao Lin, Shanghai (CN); Xi Li, Shanghai (CN); and Hongxia Shen, Shanghai (CN)
Assigned to Duality Biologics (Suzhou) Co., Ltd., Shanghai (CN)
Filed by DUALITY BIOLOGICS (SUZHOU) CO., LTD., Shanghai (CN)
Filed on Mar. 22, 2023, as Appl. No. 18/187,935.
Application 18/187,935 is a continuation of application No. 17/825,090, filed on May 26, 2022, granted, now 11,685,742.
Application 17/825,090 is a continuation of application No. PCT/CN2021/121721, filed on Sep. 29, 2021.
Claims priority of application No. 202011061580.7 (CN), filed on Sep. 30, 2020.
Prior Publication US 2023/0331738 A1, Oct. 19, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61P 35/00 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); C07D 491/22 (2006.01)
CPC A61K 47/65 (2017.08) [A61K 47/6803 (2017.08); A61K 47/68037 (2023.08); A61K 47/6855 (2017.08); A61P 35/00 (2018.01); C07D 491/22 (2013.01)] 16 Claims
 
1. A compound of general formula (II-Ex) or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein, X1 is saturated C, and X1 is substituted with Rn;
ring A is a four-membered saturated carbocyclyl;
p is 1, and L2 is not Rn;
L2 is —R2-L3-;
L3 is —(C(R3a)(R3b))m—, and m is selected from the group consisting of integers from 0 to 2, wherein when L3 comprises a methylene unit, 0 or 1 methylene unit of L3 may be replaced by —C(O)—;
R2 is —O—;
L1 is —(C(R5a)(R5b))n—, and n is selected from 0 or 1;
wherein when L1 comprises a methylene unit, 0 or 1 methylene unit of L1 may be replaced by —C(O)—;
wherein each R3a, each R3b, each R5a, each R5b and each Rn may each independently be hydrogen, halogen, or a C1-6 aliphatic group which may be optionally substituted with Rn;
wherein each R may independently be hydrogen or halogen.