US 12,434,033 B2
Gas delivery devices
Gergely Lautner, Ann Arbor, MI (US); Blake Stringer, Ypsilanti, MI (US); Elizabeth J. Brisbois, Athens, GA (US); Mark E. Meyerhoff, Ann Arbor, MI (US); and Steven P. Schwendeman, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Appl. No. 17/279,448
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Sep. 27, 2019, PCT No. PCT/US2019/053534
§ 371(c)(1), (2) Date Mar. 24, 2021,
PCT Pub. No. WO2020/069368, PCT Pub. Date Apr. 2, 2020.
Claims priority of provisional application 62/737,484, filed on Sep. 27, 2018.
Prior Publication US 2022/0111173 A1, Apr. 14, 2022
Int. Cl. A61M 16/12 (2006.01); A61M 15/00 (2006.01); A61M 16/00 (2006.01); A61M 16/10 (2006.01)
CPC A61M 16/12 (2013.01) [A61M 15/0003 (2014.02); A61M 16/0003 (2014.02); A61M 16/105 (2013.01); A61M 2016/102 (2013.01); A61M 2202/0275 (2013.01); A61M 2205/587 (2013.01)] 38 Claims
OG exemplary drawing
 
1. A gas delivery device, comprising:
a nitric oxide (NO) generating system, including:
a chamber having interior and exterior surfaces;
an NO cartridge contained within the chamber, the NO cartridge including:
a substrate;
a solid, light sensitive NO donor immobilized on a surface of the substrate; and
an NO permeable and light transparent membrane positioned on the solid, light sensitive NO donor; and
a light source attached to either i) the exterior surface or ii) the interior surface and spaced from the NO cartridge, wherein the light source is operatively positioned on the exterior or interior surface to selectively expose the solid, light sensitive NO donor to light to generate NO gas;
an inspiratory gas conduit operatively connected to the chamber to introduce an oxygen-containing gas and form an output gas including the NO gas; and
an outlet conduit to transport a stream of the output gas from the NO generating system.