	US 12,433,958 B2
	Self-therapeutic nanoparticle for enhanced topical delivery to skin keratinocytes and treating skin inflammation
Chung Hang Jonathan Choi, Hong Kong (CN); Ruifang Han, Henan (CN); and Lok Wai Cola Ho, Hong Kong (CN)
Assigned to The Chinese University of Hong Kong, Hong Kong (CN)
Filed by The Chinese University of Hong Kong, Hong Kong (CN)
Filed on Feb. 25, 2022, as Appl. No. 17/652,559.
Claims priority of provisional application 63/153,680, filed on Feb. 25, 2021.
Prior Publication US 2023/0048258 A1, Feb. 16, 2023
Int. Cl. A61K 47/69 (2017.01); A61K 9/00 (2006.01); A61K 47/60 (2017.01)

CPC A61K 47/6929 (2017.08) [A61K 9/0014 (2013.01); A61K 47/60 (2017.08)]

7 Claims

1. A composition for transdermal delivery of nanoparticles and entry into skin cells, the composition comprising:

a core comprising at least one gold nanoparticle;

a shell comprising a plurality of polyethylene glycol (PEG) strands conjugated to the core; and

a plurality of alkyl functional groups conjugated to the shell of PEG strands, the PEG strands having a molecular weight of about 1000 Da;

wherein chain loading of the plurality of alkyl functional groups is in a range greater than 0 mol % and smaller than or equal to 50 mol %,

wherein an overall diameter of the composition is smaller than 15 nm and greater than 0.0 nm, and

wherein a density of the plurality of PEG strands attached to outer surfaces of the core in terms of number of PEG strands per nm²is one of following values: 5.73±0.03, 5.56±0.09, 5.07±0.14, 5.59±0.13, 5.12±0.22, 5.6±0.1, 5.14±0.15, 5.44±0.32, 4.87±0.11, 6.07±0.62, 4.92±0.08, 3.98±0.88, or 3.36±1.24.