	US 12,433,955 B2
	Targeting cancer cells and tissue using filamentous plant virus particles
Nicole F. Steinmetz, San Diego, CA (US); and Sourabh Shukla, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by Case Western Reserve University, Cleveland, OH (US)
Filed on Feb. 13, 2024, as Appl. No. 18/440,126.
Application 18/440,126 is a continuation of application No. 16/988,210, filed on Aug. 7, 2020, granted, now 11,896,676, issued on Feb. 13, 2024.
Prior Publication US 2024/0261428 A1, Aug. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01)

CPC A61K 47/6901 (2017.08) [A61K 47/10 (2013.01); A61K 45/06 (2013.01)]

7 Claims

1. A filamentous plant virus carrier, comprising:

a pepino mosaic virus (PepMV) particle that has been modified to carry an imaging agent or anticancer agent, wherein the filamentous plant virus carrier targets cancer tissue selected from the group consisting of ovarian cancer or triple negative breast cancer (TNBC) and has increased tumor homing to triple negative breast cancer (TNBC) tumors and to ovarian cancer tumors compared to a potato virus X (PVX) carrier; and

wherein the PepMV carrier has 1.5-fold increase in tumor homing in triple negative breast cancer (TNBC) tumors and 2-fold increase in tumor homing in ovarian cancer tumors compared to a potato virus X (PVX) carrier.