	US 12,433,937 B2
	Aptamer assemblies for protein crosslinking
Bryan D. James, Gainesville, FL (US); and Josephine Allen, Gainesville, FL (US)
Assigned to University of Florida Research Foundation, Inc., Gainesville, FL (US)
Appl. No. 17/636,715
Filed by University of Florida Research Foundation, Inc., Gainesville, FL (US)
PCT Filed Aug. 28, 2020, PCT No. PCT/US2020/048488 § 371(c)(1), (2) Date Feb. 18, 2022, PCT Pub. No. WO2021/041870, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/968,129, filed on Jan. 30, 2020.
Claims priority of provisional application 62/968,130, filed on Jan. 30, 2020.
Claims priority of provisional application 62/937,316, filed on Nov. 19, 2019.
Claims priority of provisional application 62/894,215, filed on Aug. 30, 2019.
Prior Publication US 2022/0331405 A1, Oct. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/39 (2006.01); C12N 15/115 (2010.01)

CPC A61K 38/39 (2013.01) [C12N 15/115 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01)]

10 Claims

1. A composition consisting essentially of collagen fibers crosslinked with a plurality of DNA aptamers, wherein the plurality of DNA aptamers are selected from SEQ ID: NO 14 or two SEQ ID NO 14 linked with a PEG₆linker.