US 12,433,932 B2
Ang (1-7) derivative oligopeptides for the treatment of pain
Meredith Hay, Tucson, AZ (US); John Konhilas, Tucson, AZ (US); Robin L. Polt, Tucson, AZ (US); Todd Vanderah, Tucson, AZ (US); Brittany Forte, Tucson, AZ (US); Tally Milnes, Tucson, AZ (US); Evan Jones, Tucson, AZ (US); and Lajos Szabo, Tucson, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US)
Filed by ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US)
Filed on Jan. 9, 2023, as Appl. No. 18/151,957.
Application 18/151,957 is a continuation of application No. 17/109,604, filed on Dec. 2, 2020, abandoned.
Application 17/109,604 is a continuation of application No. 16/441,767, filed on Jun. 14, 2019, granted, now 10,881,708, issued on Jan. 5, 2021.
Application 16/441,767 is a continuation of application No. PCT/US2018/012893, filed on Jan. 9, 2018.
Application PCT/US2018/012893 is a continuation in part of application No. 15/401,944, filed on Jan. 9, 2017, granted, now 10,183,055, issued on Jan. 22, 2019.
Application 15/401,944 is a continuation of application No. 15/134,073, filed on Apr. 20, 2016, granted, now 9,670,251, issued on Jun. 6, 2017.
Application 15/134,073 is a continuation of application No. 14/801,557, filed on Jul. 16, 2015, granted, now 9,796,759, issued on Oct. 24, 2017.
Claims priority of provisional application 62/027,219, filed on Jul. 21, 2014.
Prior Publication US 2023/0226140 A1, Jul. 20, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/08 (2019.01); C07K 7/06 (2006.01); C07K 7/14 (2006.01); C07K 9/00 (2006.01)
CPC A61K 38/085 (2013.01) [C07K 7/06 (2013.01); C07K 7/14 (2013.01); C07K 9/001 (2013.01)] 1 Claim
 
1. A method for treating a painful condition in a subject comprising administering a therapeutically effective amount of an oligopeptide having the formula: A1-A2-A3-A4-A5-A6-A7-A8 (SEQ ID NO:10) wherein
A1 is aspartic acid;
A2 is arginine;
A3 is valine;
A4 is tyrosine;
A5 is isoleucine;
A6 is histidine;
A7 is serine; and
A8 is absent,
wherein the painful condition is selected from the group consisting of acute pain, trauma-induced pain, dental pain, and osteoarthritis,
wherein the oligopeptide is glycosylated with a monosaccharide or disaccharide.