	US 12,433,920 B2
	C. novyi for the treatment of solid tumors in non-human animals
Saurabh Saha, Wellesley Hills, MA (US); Shibin Zhou, Owings Mills, MD (US); Bert Vogelstein, Baltimore, MD (US); and Kenneth W. Kinzler, Bel Air, MD (US)
Assigned to Biomed Valley Discoveries, Inc., Kansas City, MO (US)
Appl. No. 14/781,270
Filed by BIOMED VALLEY DISCOVERIES, INC., Kansas City, MO (US); and THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
PCT Filed Mar. 28, 2014, PCT No. PCT/US2014/032224 § 371(c)(1), (2) Date Sep. 29, 2015, PCT Pub. No. WO2014/160967, PCT Pub. Date Oct. 2, 2014.
Claims priority of provisional application 61/806,484, filed on Mar. 29, 2013.
Prior Publication US 2016/0045556 A1, Feb. 18, 2016
Int. Cl. A61K 35/74 (2015.01); A61K 31/65 (2006.01); A61K 45/06 (2006.01)

CPC A61K 35/74 (2013.01) [A61K 31/65 (2013.01); A61K 45/06 (2013.01)]

39 Claims

1. A method for debulking a solid tumor present in a non-human animal comprising administering intratumorally to the non-human animal a plurality of treatment cycles of a unit dose of C. novyi colony forming units (CFUs) comprising 1×10⁶-1×10¹⁰CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is the only administered anti-tumor treatment, and wherein the solid tumor is a mast cell tumor.