US 12,433,911 B2
Preparation and storage of liposomal RNA formulations suitable for therapy
Heinrich Haas, Mainz (DE); Sebastian Hörner, Mainz (DE); and Thomas Michael Hiller, Mainz (DE)
Assigned to BioNTech SE, Mainz (DE)
Appl. No. 17/593,391
Filed by BIONTECH SE, Mainz (DE)
PCT Filed Apr. 1, 2020, PCT No. PCT/EP2020/059308
§ 371(c)(1), (2) Date Sep. 17, 2021,
PCT Pub. No. WO2020/201383, PCT Pub. Date Oct. 8, 2020.
Claims priority of application No. PCT/EP2019/058635 (WO), filed on Apr. 5, 2019.
Prior Publication US 2022/0143069 A1, May 12, 2022
Int. Cl. A61K 31/7105 (2006.01); A61K 47/02 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01)
CPC A61K 31/7105 (2013.01) [A61K 47/02 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01)] 37 Claims
OG exemplary drawing
 
1. A composition comprising:
RNA lipoplex particles comprising:
RNA, and
at least one cationic lipid and at least one additional lipid,
sodium chloride at a concentration of about 10 mM or less,
a stabilizer at a concentration of about 10% weight by volume percent (% w/v) or less, and a buffer.