	US 12,433,909 B2
	Formulations of cyclic macromolecule-based nanoparticles encapsulating small molecules
Sauradip Chaudhuri, Houston, TX (US); and Rachael Sirianni, Sugar Land, TX (US)
Assigned to BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/613,197
Filed by Board of Regents of The University of Texas System, Austin, TX (US)
PCT Filed Mar. 25, 2020, PCT No. PCT/US2020/024627 § 371(c)(1), (2) Date Nov. 22, 2021, PCT Pub. No. WO2020/236305, PCT Pub. Date Nov. 26, 2020.
Claims priority of provisional application 62/850,308, filed on May 20, 2019.
Prior Publication US 2022/0305043 A1, Sep. 29, 2022
Int. Cl. A61K 31/7068 (2006.01); A61K 9/51 (2006.01); A61K 31/4045 (2006.01); A61K 31/4745 (2006.01); A61K 31/506 (2006.01); A61K 31/538 (2006.01)

CPC A61K 31/7068 (2013.01) [A61K 9/5161 (2013.01); A61K 31/4045 (2013.01); A61K 31/4745 (2013.01); A61K 31/506 (2013.01); A61K 31/538 (2013.01)]

25 Claims

1. A composition comprising:

particles comprising a cross-linked network of cyclic macromolecules, wherein the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents, and at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups; and

an active agent, wherein the active agent is ionized,

wherein:

the plurality of functional groups comprise a chain of at least three atoms that protrude out of the cross-linking agents, and

the active agent is associated with the particles.