US 12,433,898 B2
Use of GABAA receptor modulators for treatment of itch
Hanns Ulrich Zeilhofer, Zurich (CH); and William Ralvenius, Somerville, MA (US)
Filed by UNIVERSITAT ZURICH, Zurich (CH)
Filed on Sep. 1, 2022, as Appl. No. 17/901,356.
Application 17/901,356 is a continuation of application No. 16/994,146, filed on Aug. 14, 2020, granted, now 11,529,359.
Application 16/994,146 is a continuation of application No. 16/045,193, filed on Jul. 25, 2018, granted, now 10,786,513, issued on Sep. 29, 2020.
Application 16/045,193 is a continuation of application No. PCT/EP2017/051866, filed on Jan. 27, 2017.
Claims priority of application No. 16153035 (EP), filed on Jan. 27, 2016; and application No. 16178824 (EP), filed on Jul. 11, 2016.
Prior Publication US 2025/0268912 A1, Aug. 28, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/5517 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/437 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 31/5513 (2006.01); A61P 17/04 (2006.01)
CPC A61K 31/5517 (2013.01) [A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/437 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/5513 (2013.01); A61P 17/04 (2018.01)] 15 Claims
OG exemplary drawing
 
1. A method for treating a pruritic condition in a subject, wherein the method comprises administering to the subject a compound with the general formula (2a″)

OG Complex Work Unit Chemistry
with
R1 being
a substituted phenyl comprising C1-C4-alkyl, F, Cl, Br, I, —CN as substituents, wherein in particular said substituted phenyl comprises at least one —F as a substituent,
R7 being
tert-butyl,
a C4-cycloalkyl,
R8 being
—O—CH2—R4, with R4 being an C1-C6 substituted or unsubstituted 5-membered heteroaryl.