US 12,433,893 B2
Alpha polyglutamated pemetrexed and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed on Jun. 1, 2023, as Appl. No. 18/204,566.
Application 18/204,566 is a division of application No. 16/967,212, granted, now 11,779,584, previously published as PCT/US2019/016989, filed on Feb. 7, 2019.
Claims priority of provisional application 62/764,943, filed on Aug. 17, 2018.
Claims priority of provisional application 62/764,955, filed on Aug. 17, 2018.
Claims priority of provisional application 62/702,732, filed on Jul. 24, 2018.
Claims priority of provisional application 62/702,561, filed on Jul. 24, 2018.
Claims priority of provisional application 62/662,374, filed on Apr. 25, 2018.
Claims priority of provisional application 62/630,629, filed on Feb. 14, 2018.
Claims priority of provisional application 62/627,741, filed on Feb. 7, 2018.
Claims priority of provisional application 62/627,703, filed on Feb. 7, 2018.
Prior Publication US 2024/0173321 A1, May 30, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/519 (2006.01); A61K 9/1271 (2025.01); A61K 31/282 (2006.01); C07K 16/28 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/1271 (2013.01); A61K 31/282 (2013.01); C07K 16/2818 (2013.01)] 25 Claims
 
1. A liposomal composition comprising a polyglutamated pemetrexed encapsulated by a pegylated liposome, wherein the polyglutamated pemetrexed comprises 2-10 glutamyl groups in the D-form that have an alpha carboxyl group linkage.