US 12,433,879 B2
Malleable controlled release local anesthetic with hemostatic composition
Khashayar Kevin Neshat, Raleigh, NC (US)
Assigned to Rilento Pharma, LLC, Raleigh, NC (US)
Filed by Rilento Pharma, LLC, Raleigh, NC (US)
Filed on May 1, 2024, as Appl. No. 18/652,317.
Application 18/652,317 is a continuation of application No. 15/405,453, filed on Jan. 13, 2017, granted, now 11,992,482.
Claims priority of provisional application 62/437,193, filed on Dec. 21, 2016.
Prior Publication US 2024/0285601 A1, Aug. 29, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/445 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 9/19 (2006.01); A61K 38/48 (2006.01); A61K 45/06 (2006.01); A61L 24/00 (2006.01); A61P 23/02 (2006.01)
CPC A61K 31/445 (2013.01) [A61K 9/06 (2013.01); A61K 9/1647 (2013.01); A61K 9/19 (2013.01); A61K 38/4833 (2013.01); A61K 45/06 (2013.01); A61L 24/0015 (2013.01); A61L 24/0036 (2013.01); A61L 24/0094 (2013.01); A61P 23/02 (2018.01); C12Y 304/21005 (2013.01); A61L 2300/402 (2013.01); A61L 2300/404 (2013.01); A61L 2300/418 (2013.01)] 7 Claims
 
1. A malleable sustained release formulation designed for packing and sticking in a dental extraction cavity, a surgical cavity or a wound cavity of a patient, the formulation comprising:
a homogenous dry blend including
a. a local anesthetic formulated into sustained release microparticles, of a size between 0.1 and 100 microns, the microparticles encapsulating the local anesthetic for forming a primary sustained release vehicle for the local anesthetic by diffusion from the microparticles;
b. an absorbable a gelatin powder, wherein the gelatin is selected from the group consisting of a bovine skin hemostatic composition agent and porcine skin hemostatic agent; and
c. an aqueous solution,
wherein the gelatin powder and the aqueous solution form a gelled matrix with the local anesthetic sustained release microparticles incorporated into and suspended within the gelled matrix such that the gelled matrix comprises a secondary sustained release vehicle for the local anesthetic microparticles by diffusion through the matrix, and
wherein the gelled matrix is a malleable putty prior to its insertion into the cavity of a patient such that a bolus of the malleable formulation can be mixed by hand under low shear ambient conditions for molding a bolus manually sized and shaped to fit the cavity and be retained therein.