US 12,433,877 B2
Sustained release drug delivery systems and related methods
Adrian Neil Verity, Helotis, TX (US); Steven Halladay, Oro Valley, AZ (US); Vaeling Miller, Sunnyvale, CA (US); Peter Langecker, Monte Sereno, CA (US); Dmitri Lissin, Redwood City, CA (US); Andrew R. Miksztal, Palo Alto, CA (US); Judy Joice, San Jose, CA (US); Susan Autio, San Jose, CA (US); and Mark P. Davis, Middleton, WI (US)
Assigned to Durect Corporation, Cupertino, CA (US)
Filed by Durect Corporation, Cupertino, CA (US)
Filed on May 13, 2022, as Appl. No. 17/744,509.
Application 17/744,509 is a continuation of application No. PCT/US2022/012050, filed on Jan. 11, 2022.
Claims priority of provisional application 63/136,616, filed on Jan. 12, 2021.
Prior Publication US 2022/0273633 A1, Sep. 1, 2022
Int. Cl. A61K 31/445 (2006.01); A61K 9/00 (2006.01); A61P 23/02 (2006.01)
CPC A61K 31/445 (2013.01) [A61K 9/0019 (2013.01); A61P 23/02 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method of producing post-surgical analgesia in a subject having arthroscopic subacromial decompression surgery, comprising:
drawing up 5 mL of a bupivacaine composition into a 5 mL syringe using a 16-gauge or larger bore needle to fill the 5 mL syringe, the bupivacaine composition comprising:
bupivacaine free base or salt thereof present in an amount ranging from 10 wt % to 15 wt %, based on weight of the bupivacaine composition,
sucrose acetate isobutyrate present in an amount ranging from 63 wt % to 67 wt %, based on weight of the bupivacaine composition, and
benzyl alcohol present in an amount ranging from 20 wt % to 25 wt %, based on weight of the bupivacaine composition;
discarding the 16-gauge or larger bore needle; and
administering the 5 mL of the bupivacaine composition into the subacromial space of the subject using an 18-gauge or larger bore needle to produce post-surgical analgesia,
wherein the method comprises arthroscopically visualizing the subacromial space to confirm placement of the 18-gauge or larger bore needle in the subacromial space prior to administering the bupivacaine composition.