US 12,433,872 B2
Treatment of Acanthamoeba or Balamuthia trophozoites and/or cysts
David W. Boykin, Atlanta, GA (US); Dennis E. Kyle, Athens, GA (US); Christopher A. Rice, Athens, GA (US); and Abdelbasset A. Farahat, Atlanta, GA (US)
Assigned to GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., Atlanta, GA (US)
Appl. No. 17/286,058
Filed by GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., Atlanta, GA (US); UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Athens, GA (US); and UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US)
PCT Filed Oct. 17, 2019, PCT No. PCT/US2019/056761
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/081829, PCT Pub. Date Apr. 23, 2020.
Claims priority of provisional application 62/746,940, filed on Oct. 17, 2018.
Prior Publication US 2022/0096441 A1, Mar. 31, 2022
Int. Cl. A61K 31/4184 (2006.01); A01N 43/52 (2006.01); A01N 43/54 (2006.01); A61K 31/155 (2006.01); A61K 31/4174 (2006.01); A61K 31/4196 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/661 (2006.01); A61K 31/7036 (2006.01); A61K 31/785 (2006.01); A61K 38/12 (2006.01); A61P 33/04 (2006.01); C07D 235/18 (2006.01); C07D 235/20 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01)
CPC A61K 31/4184 (2013.01) [A01N 43/52 (2013.01); A01N 43/54 (2013.01); A61K 31/155 (2013.01); A61K 31/4174 (2013.01); A61K 31/4196 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/661 (2013.01); A61K 31/7036 (2013.01); A61K 31/785 (2013.01); A61K 38/12 (2013.01); A61P 33/04 (2018.01); C07D 235/18 (2013.01); C07D 235/20 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01)] 28 Claims
 
1. A compound of Formula 2 or Formula 3:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
wherein:
R3 and R4 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R3 and R4 is not hydrogen;
R5 is selected from halo, C1-C4alkoxy, and C1-C4haloalkyl;
R6 and R7 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R6 and R7 is not hydrogen;
R8 is selected from halo, C1-C4alkoxy, and C1-C4haloalkyl;
R9 and R10 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R9 and R10 is not hydrogen;
RX and RY are independently selected at each occurrence from halo, C1-4alkoxy, and C1-C4haloalkyl;
o and p are independently selected 0, 1, 2, and 3; and
RA and RB are independently C1-C6alkyl.