	US 12,433,871 B2
	Effects of age-dependent changes in cell size on endothelial cell growth
Akiko Mammoto, Pewaukee, WI (US); and Tadamori Mammoto, Pewaukee, WI (US)
Assigned to The Medical College of Wisconsin, Inc., Milwaukee, WI (US)
Appl. No. 17/439,382
Filed by The Medical College of Wisconsin, Inc., Milwaukee, WI (US)
PCT Filed Mar. 12, 2020, PCT No. PCT/US2020/022277 § 371(c)(1), (2) Date Sep. 14, 2021, PCT Pub. No. WO2020/209972, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/819,055, filed on Mar. 15, 2019.
Prior Publication US 2022/0175730 A1, Jun. 9, 2022
Int. Cl. A61K 31/415 (2006.01); A61K 9/06 (2006.01); G01N 1/30 (2006.01)

CPC A61K 31/415 (2013.01) [A61K 9/06 (2013.01); G01N 1/30 (2013.01)]

18 Claims

1. A method of stimulating angiogenesis in a subject in need thereof comprising the step of: administering to the subject a therapeutically effective amount of ML141, whereby angiogenesis in the subject is stimulated, wherein the therapeutically effective amount of ML141 is administered as a composition having a ML 141 concentration of 0.1 μM to less than 15 μM.