US 12,433,870 B2
Supramolecular photoprotection of a photosensitizer
Indranil Roy, Chicago, IL (US); and James Fraser Stoddart, Evanston, IL (US)
Assigned to Northwestern University, Evanston, IL (US); and King Abdulaziz City for Science and Technology (KACST), Riyadh (SA)
Appl. No. 17/426,633
Filed by Northwestern University, Evanston, IL (US); and King Abdulaziz City for Science and Technology (KACST), Riyadh (SA)
PCT Filed Jan. 31, 2020, PCT No. PCT/US2020/016064
§ 371(c)(1), (2) Date Jul. 29, 2021,
PCT Pub. No. WO2020/160382, PCT Pub. Date Aug. 6, 2020.
Claims priority of provisional application 62/799,229, filed on Jan. 31, 2019.
Prior Publication US 2022/0133692 A1, May 5, 2022
Int. Cl. A61K 31/409 (2006.01); A61K 41/00 (2020.01); A61P 35/00 (2006.01); C07D 487/22 (2006.01)
CPC A61K 31/409 (2013.01) [A61K 41/0057 (2013.01); A61P 35/00 (2018.01); C07D 487/22 (2013.01)] 6 Claims
 
1. A pharmaceutical composition comprising water-soluble host-guest complex formed from a host receptor and a guest photosensitizer,
wherein the photosensitizer comprises a macrocyclic pyrrole,
wherein the receptor host is a cyclophane, and
one or more pharmaceutically acceptable carriers, excipients, or diluents,
wherein the pharmaceutical composition comprises an effective amount of the guest photosensitizer for treating a cell proliferative disease or disorder.