US 12,433,856 B2
Petrolatum-based compositions and methods of treatment for onychomycosis
Bradley Burnam, Calabasas, CA (US)
Assigned to GLOBAL HEALTH SOLUTIONS LLC
Filed by GLOBAL HEALTH SOLUTIONS LLC, Rome, GA (US)
Filed on Sep. 8, 2021, as Appl. No. 17/468,809.
Application 17/468,809 is a continuation of application No. 16/745,308, filed on Jan. 16, 2020, granted, now 11,116,734.
Application 16/745,308 is a continuation in part of application No. 15/167,099, filed on May 27, 2016, granted, now 10,722,461, issued on Jul. 28, 2020.
Claims priority of provisional application 62/338,995, filed on May 19, 2016.
Claims priority of provisional application 62/319,449, filed on Apr. 7, 2016.
Claims priority of provisional application 62/182,034, filed on Jun. 19, 2015.
Prior Publication US 2021/0401779 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/14 (2006.01); A61K 31/135 (2006.01); A61K 31/4164 (2006.01); A61K 31/4412 (2006.01); A61K 45/06 (2006.01); A61K 47/06 (2006.01); A61P 31/10 (2006.01)
CPC A61K 31/14 (2013.01) [A61K 31/135 (2013.01); A61K 31/4164 (2013.01); A61K 31/4412 (2013.01); A61K 45/06 (2013.01); A61K 47/06 (2013.01); A61P 31/10 (2018.01)] 20 Claims
 
1. A petrolatum-based composition for the treatment of onychomycosis, the composition comprising a pharmaceutically effective amount of one or more anti-fungal agents in a petrolatum carrier, wherein the one or more anti-fungal agents is dissolved in a polar solvent to form an anti-fungal agent solution, the anti-fungal agent solution dispersed in the petrolatum to form a stable suspension, wherein the one or more anti-fungal agents comprises from about 0.5% to about 2.5% by weight of the petrolatum-based composition, the one or more anti-fungal agents is selected from the group consisting of terbinafine HCl, ciclopirox, ciclopirox olamine, fluconazole, itraconazole, ketoconazole, amorolfine, efinaconazole, clotrimazole, miconazole nitrate, and any combination thereof, and wherein the petrolatum-based composition comprises greater than about 90% by weight petrolatum.