	US 12,433,855 B2
	Method of inhibiting gram-negative bacterial quorum signalling molecules using the macrocycle pillar[5]arene
Christopher Jonkergouw, Aalto (FI); Kodiah Beyeh, Aalto (FI); Ekaterina Osmekhina, Aalto (FI); Robin Ras, Aalto (FI); and Markus Linder, Aalto (FI)
Assigned to AALTO UNIVERSITY FOUNDATION SR, Aalto (FI)
Appl. No. 17/283,471
Filed by AALTO UNIVERSITY FOUNDATION SR, Aalto (FI)
PCT Filed Oct. 8, 2019, PCT No. PCT/FI2019/050717 § 371(c)(1), (2) Date Apr. 7, 2021, PCT Pub. No. WO2020/074776, PCT Pub. Date Apr. 16, 2020.
Claims priority of application No. 20185841 (FI), filed on Oct. 8, 2018.
Prior Publication US 2022/0008364 A1, Jan. 13, 2022
Int. Cl. A61P 31/04 (2006.01); A61K 31/14 (2006.01); A61K 31/185 (2006.01); A61K 31/357 (2006.01); A61K 31/4188 (2006.01); A61K 31/724 (2006.01)

CPC A61K 31/14 (2013.01) [A61K 31/185 (2013.01); A61K 31/357 (2013.01); A61K 31/4188 (2013.01); A61K 31/724 (2013.01); A61P 31/04 (2018.01)]

6 Claims

1. A method to inhibit a microbial quorum signalling molecule or to reduce the amount of a microbial quorum signalling molecule produced by a Gram-negative bacteria in a subject, by binding the microbial quorum signaling molecule selected from homoserine lactones (HSLs) or N-acyl homoserine lactones (AHLs) by non-covalent host-guest bonding by a macrocyclic cavity-containing compound, wherein the method comprises contacting the macrocyclic, cavity-containing compound selected from pillar[5]arenes and/or salts thereof with said subject.