US 12,433,852 B2
Self-adhesive patches made of fibres for the controlled release of bioactives
Jose Maria Lagaron Cabello, Valencia (ES); Cristina Prieto López, Valencia (ES); María de Las Mercedes Pardo Figuérez, Valencia (ES); and Jorge Teno Díaz, Valencia (ES)
Assigned to BIONANOPHARMA S.L., Valencia (ES); and CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), Madrid (ES)
Appl. No. 17/924,049
Filed by BIOINICIA, S.L., Valencia (ES); and CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), Madrid (ES)
PCT Filed Apr. 29, 2021, PCT No. PCT/ES2021/070294
§ 371(c)(1), (2) Date Nov. 8, 2022,
PCT Pub. No. WO2021/229119, PCT Pub. Date Nov. 18, 2021.
Claims priority of application No. ES202030423 (ES), filed on May 11, 2020.
Prior Publication US 2023/0270688 A1, Aug. 31, 2023
Int. Cl. A61K 9/70 (2006.01); A61F 13/02 (2006.01); A61K 8/02 (2006.01); A61K 8/73 (2006.01); A61K 8/81 (2006.01); A61K 8/85 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 47/38 (2006.01); D01D 5/00 (2006.01); D04H 1/425 (2012.01); D04H 1/4282 (2012.01); D04H 1/435 (2012.01); D04H 1/559 (2012.01); D04H 1/728 (2012.01)
CPC A61K 9/7084 (2013.01) [A61F 13/0283 (2013.01); A61K 8/0233 (2013.01); A61K 8/731 (2013.01); A61K 8/8176 (2013.01); A61K 8/85 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01); D01D 5/0038 (2013.01); D01D 5/0092 (2013.01); D04H 1/425 (2013.01); D04H 1/4282 (2013.01); D04H 1/435 (2013.01); D04H 1/559 (2013.01); D04H 1/728 (2013.01); A61F 2013/0296 (2013.01); D10B 2331/04 (2013.01); D10B 2331/041 (2013.01); D10B 2509/00 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A self-adhesive patch as a platform for controlled release of bioactives comprising at least:
i) a first block A which is in contact with the corporal mucosa or skin to which it adheres characterised in that it is formed by at least one layer made of hydrophilic polymers, and in that it has a surface density of at least 0.2 g/m2, wherein the hydrophilic polymers of the block A form an emulsified mixture of polyethylene oxide and polyvinylpyrrolidone;
ii) a second block B deposited on the block A obtained by electrohydrodynamic processing, aerodynamic processing or combination of the two, containing the encapsulated bioactive(s), characterised in that it is formed by at least one layer of fibres made of at least one hydrophobic polymer, and in that it has a surface density of at least 0.2 g/m2;
iii) a third block C deposited on the block B, wherein the block C is formed by at least one layer, characterized in that it is obtained by electrohydrodynamic processing, aerodynamic processing or combination of the two and made up of one or more hydrophobic polymers which are selected from poly-ε-caprolactone, poly-ε-caprolactone copolymers, polylactic acid and the copolymers thereof, and polyhydroxyalkanoates, or any of the mixtures thereof, and in that it has a surface density of at least 0.2 g/m2.