US 12,433,851 B2
Controlling water release from a dimensionally stable aqueous composition
Florian Hammes, Andernach (DE); and René Eifler, Koblenz (DE)
Assigned to LTS Lohmann Therapie-Systeme AG, Andernach (DE)
Filed by LTS Lohmann Therapie-Systeme AG, Andernach (DE)
Filed on Aug. 9, 2023, as Appl. No. 18/446,645.
Application 18/446,645 is a division of application No. 16/071,156, granted, now 11,752,109, previously published as PCT/EP2017/050866, filed on Jan. 17, 2017.
Claims priority of application No. 16152059 (EP), filed on Jan. 20, 2016.
Prior Publication US 2023/0381116 A1, Nov. 30, 2023
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 31/485 (2006.01); A61P 25/04 (2006.01)
CPC A61K 9/7061 (2013.01) [A61K 9/0014 (2013.01); A61K 31/485 (2013.01)] 19 Claims
 
1. A self-destructing transdermal therapeutic system (TTS) comprising
(i) at least one active ingredient,
(ii) at least one water-soluble agent that renders the active ingredient unusable,
(iii) a separation between the active ingredient and the at least one water-soluble agent that renders the active ingredient unusable, and
(iv) a liquid-tight packaging comprising
(a) a hydrous composition comprising a gel whose liquid phase consists substantially of water; and
(b) a sufficient amount of an activating agent to release the liquid phase from said gel after a temporal delay; and
(v) an at least one mechanical means for opening, perforating or destroying said liquid-tight packaging disposed either within the liquid-tight packaging or affixed to the outside of the liquid-tight packaging,
wherein when the TTS is removed after use the at least one mechanical means opens, perforates or destroys the liquid tight packaging, resulting in an ingress of the liquid phase to the at least one water-soluble agent that undoes the separation between the active ingredient and the at least one water-soluble agent so that the active ingredient and the at least one water-soluble agent come into contact with one another and this contact destroys the active ingredient.