US 12,433,845 B2
Peptide-functionalized biodegradable polymers for efficient delivery of various RNAs
Zhibin Guan, Irvine, CA (US); Dongchu Yang, Irvine, CA (US); and Alexander Eldredge, Irvine, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/432,077
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Feb. 21, 2020, PCT No. PCT/US2020/019375
§ 371(c)(1), (2) Date Aug. 18, 2021,
PCT Pub. No. WO2020/172642, PCT Pub. Date Aug. 27, 2020.
Claims priority of provisional application 62/809,550, filed on Feb. 22, 2019.
Prior Publication US 2022/0183990 A1, Jun. 16, 2022
Int. Cl. A61K 9/51 (2006.01); A61K 9/08 (2006.01); A61K 9/48 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 39/00 (2006.01); A61K 47/59 (2017.01); A61K 47/64 (2017.01)
CPC A61K 9/5146 (2013.01) [A61K 9/08 (2013.01); A61K 9/4841 (2013.01); A61K 31/7105 (2013.01); A61K 31/713 (2013.01); A61K 47/59 (2017.08); A61K 47/6455 (2017.08); A61K 39/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A peptide-functionalized biodegradable polymer (PFBP) that is biocompatible and can form a complex or polyplex with nucleic acids and release the nucleic acids within a cell,
wherein the PFBP comprises the structure of Formula I(a):

OG Complex Work Unit Chemistry
wherein,
n is an integer greater than 10;
X1 and X2 have the structure of Formula II:

OG Complex Work Unit Chemistry
wherein,
X3 and X4 are independently selected from a cell penetrating peptide (CPP) consisting of the sequence of SEQ ID NO:21, a fatty acid, or a polyoxyalkylene polymer, wherein at least one of X3 and X4 is a CPP consisting of the sequence of SEQ ID NO:21.