	US 12,433,840 B2
	Melt processed viral nanoparticle constructs
Nicole F. Steinmetz, San Diego, CA (US); and Jonathan Pokorski, San Diego, CA (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Feb. 18, 2022, as Appl. No. 17/675,605.
Application 17/675,605 is a continuation in part of application No. 16/347,503, granted, now 11,654,117, previously published as PCT/US2017/059935, filed on Nov. 3, 2017.
Claims priority of provisional application 63/150,976, filed on Feb. 18, 2021.
Claims priority of provisional application 62/417,000, filed on Nov. 3, 2016.
Prior Publication US 2022/0211628 A1, Jul. 7, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C08K 11/00 (2006.01)

CPC A61K 9/1647 (2013.01) [A61K 39/00 (2013.01); C08K 11/00 (2013.01); A61K 38/00 (2013.01); A61K 2039/54 (2013.01); C08K 2201/011 (2013.01)]

22 Claims

1. A construct comprising:

a melt processed blend of a biodegradable polymer and viral nanoparticles, wherein the viral nanoparticles are encapsulated within a biodegradable polymer matrix of the biodegradable polymer, the viral nanoparticles including a plurality of immunogenic peptides conjugated to the viral nanoparticles, the construct upon administration to a subject providing sustained release of the viral nanoparticles and conjugated immunogenic peptides from the matrix to the subject, the released viral nanoparticles and conjugated immunogenic peptides eliciting an immunogenic response in the subject.