| CPC A61F 2/2412 (2013.01) [A61F 2/2409 (2013.01); A61F 2/2418 (2013.01); A61F 2/2427 (2013.01); A61F 2/2445 (2013.01); A61F 2/246 (2013.01); A61F 2210/0014 (2013.01); A61F 2220/0008 (2013.01); A61F 2220/0016 (2013.01); A61F 2230/0069 (2013.01); A61F 2250/006 (2013.01); A61F 2250/0063 (2013.01)] | 26 Claims |

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1. A system for replacing a native valve of the heart, the native valve having a native annulus and native valve leaflets, the system comprising:
a delivery apparatus comprising a sheath and a pusher shaft extending through the sheath, wherein the delivery apparatus is steerable within a vasculature of a patient; and
a prosthetic valve comprising:
a main body comprising a lumen and configured for placement within the native annulus, the main body being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state;
a valve structure coupled to the inner surface of the main body, the valve structure comprising a plurality of valve leaflets that form a one-way valve in the lumen;
at least two ventricular anchors extending from a ventricular end portion of the main body and disposed outside of the main body for securing the prosthetic valve to the native leaflets, wherein the ventricular anchors are configured to capture the native valve leaflets between the ventricular anchors and an outer surface of the main body;
wherein each ventricular anchor is finger-like and extends from at least one attachment point on the ventricular end portion of the main body and wherein each ventricular anchor is pre-formed to extend along the outer surface of the main body in a functional deployed state;
wherein the prosthetic valve is disposed within a distal end portion of the sheath with main body of the frame retained in the radially compressed state and the ventricular anchors retained in a partially or completely straightened configuration extending distally from the ventricular end portion of the main body, and wherein an atrial end of the main body is releasably attached to the pusher shaft;
wherein the ventricular anchors are configured to be deployed from the sheath while the main body is still retained in the radially compressed state, which allows the ventricular anchors to spring back from the straightened configuration to the functional deployed state, wherein the main body is configured to deployed from the sheath and expand from the radially compressed state to the radially expanded state after the ventricular anchors have been deployed from the sheath;
wherein the delivery apparatus is configured to deliver the prosthetic valve to the native valve in a trans-septal delivery approach in which the delivery apparatus extends through an atrial septum of the heart.
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