US 12,433,680 B2
Automatic, patient-specific targeting for deep brain stimulation
Chen Li, Lebanon, NH (US); Damon Hyde, Somerville, MA (US); and Lyubomir Zagorchev, Burlington, MA (US)
Assigned to ClearPoint Neuro, Inc., Solana Beach, CA (US)
Filed by ClearPoint Neuro, Inc., Solana Beach, CA (US)
Filed on Feb. 15, 2023, as Appl. No. 18/169,583.
Prior Publication US 2024/0268891 A1, Aug. 15, 2024
Int. Cl. A61B 34/10 (2016.01); A61N 1/05 (2006.01); G06T 17/20 (2006.01); G06T 19/20 (2011.01); G16H 50/70 (2018.01)
CPC A61B 34/10 (2016.02) [G06T 17/20 (2013.01); G06T 19/20 (2013.01); G16H 50/70 (2018.01); A61B 2034/105 (2016.02); A61B 2034/107 (2016.02); A61N 1/0534 (2013.01); G06T 2219/2021 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method, comprising:
adapting a shape-constrained deformable cranial region model to a scan of a patient's brain, to generate a patient-specific three-dimensional (3D) mesh representation of a brain structure of the patient, the brain structure being targeted for a prospective deep brain stimulation (DBS) procedure and the shape-constrained deformable cranial region model comprising a computerized 3D mesh representation of a non-patient-specific human cranial region that preserves mesh vertex-based correspondences during mesh adaption to patient scans;
computing center of mass coordinates for the brain structure based on coordinates of mesh vertices of the patient-specific 3D mesh representation of the brain structure;
determining an average spatial offset between center of mass coordinates for corresponding brain structures and DBS lead placement coordinates from historical DBS procedures;
predicting DBS lead placement coordinates for the prospective DBS procedure based on the computed center of mass coordinates for the brain structure of the patient and the determined average spatial offset; and
displaying, on a graphical user interface (GUI), the predicted DBS lead placement coordinates in relationship to a representation of the patient's brain.