US 12,433,673 B2
Device for inducing cell death
Johannes Benedikt, Cardiff (GB); Robert Edward Mansel, Cardiff (GB); Wen Guo Jiang, Cardiff (GB); Tracey Amanda Martin, Cardiff (GB); and Philippa Young, Cardiff (GB)
Assigned to University College Cardiff Consultants Limited, Cardiff (GB)
Appl. No. 17/608,304
Filed by University College Cardiff Consultants Limited, Cardiff (GB)
PCT Filed May 1, 2020, PCT No. PCT/GB2020/051086
§ 371(c)(1), (2) Date Nov. 2, 2021,
PCT Pub. No. WO2020/222020, PCT Pub. Date Nov. 5, 2020.
Claims priority of application No. 1906172 (GB), filed on May 2, 2019.
Prior Publication US 2022/0249162 A1, Aug. 11, 2022
Int. Cl. A61B 18/18 (2006.01); A61N 1/36 (2006.01); A61N 1/40 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1815 (2013.01) [A61N 1/36002 (2017.08); A61N 1/40 (2013.01); A61B 2018/00333 (2013.01); A61B 2018/00642 (2013.01); A61B 2018/00678 (2013.01); A61B 2018/00708 (2013.01); A61B 2018/00714 (2013.01); A61B 2018/00785 (2013.01); A61B 2018/00815 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A medical device for inducing cell death in cancer cells, the medical device comprising:
a signal generator arranged to generate a pulsed electrical signal, and
a probe comprising a transmitter, the transmitter being arranged to receive the pulsed electrical signal and generate, in response to the pulsed electrical signal, an electromagnetic field in a treatment volume;
wherein the electromagnetic field is generated at, and radiates from, a free end of the transmitter in use; and
wherein the medical device is arranged such that the pulsed electrical signal received by the transmitter has:
a pulse width in a range of 0.1 microsecond to 1 millisecond, and
a signal frequency in a range of 100 Megahertz to 20 Gigahertz; and
wherein the transmitter is a broadband transmitter configured to generate the electromagnetic field in response to the pulsed electrical signal over a range of signal frequencies from 100 MHz to 20 GHz.