US 12,433,577 B2
Apparatus and methods for sealing a vascular puncture
Andy H. Uchida, Los Altos, CA (US); Anthony P. Spizuoco, San Francisco, CA (US); Kevin To, San Jose, CA (US); Florencia Lim, Union City, CA (US); and Scott R Sershen, Foster City, CA (US)
Assigned to ACCESS CLOSURE, INC., Mountain View, CA (US)
Filed by Access Closure, Inc., Santa Clara, CA (US)
Filed on Aug. 30, 2021, as Appl. No. 17/446,386.
Application 16/055,736 is a division of application No. 13/354,278, filed on Jan. 19, 2012, granted, now 10,182,800, issued on Jan. 22, 2019.
Application 17/446,386 is a continuation of application No. 16/055,736, filed on Aug. 6, 2018, granted, now 11,103,224.
Claims priority of provisional application 61/434,412, filed on Jan. 19, 2011.
Prior Publication US 2022/0225975 A1, Jul. 21, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 17/00 (2006.01); A61L 24/02 (2006.01); C08L 71/02 (2006.01); A61B 17/22 (2006.01); A61B 90/90 (2016.01)
CPC A61B 17/0057 (2013.01) [A61L 24/02 (2013.01); C08L 71/02 (2013.01); A61B 2017/00495 (2013.01); A61B 2017/00526 (2013.01); A61B 2017/00561 (2013.01); A61B 2017/0065 (2013.01); A61B 2017/00871 (2013.01); A61B 2017/00884 (2013.01); A61B 2017/00889 (2013.01); A61B 2017/00893 (2013.01); A61B 2017/00898 (2013.01); A61B 2017/00951 (2013.01); A61B 2017/22067 (2013.01); A61B 2017/22069 (2013.01); A61B 90/90 (2016.02)] 41 Claims
 
1. A sealant for sealing a puncture through tissue, comprising:
an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, the first section formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within the puncture; and
a second section fused to and extending from the distal end of the first section, the second section formed from non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section.