US 12,433,549 B1
Molecular imaging of the cochlea
Parveen Bazard, Tampa, FL (US); Mikalai Budzevich, Tampa, FL (US); Xiaoxia Zhu, Tampa, FL (US); Bo Ding, Tampa, FL (US); and Robert Dana Frisina, Tampa, FL (US)
Assigned to University of South Florida, Tampa, FL (US); and H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US)
Filed by University of South Florida, Tampa, FL (US); and H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US)
Filed on Jan. 30, 2024, as Appl. No. 18/426,829.
Claims priority of provisional application 63/482,079, filed on Jan. 30, 2023.
Int. Cl. A61B 6/03 (2006.01); A61B 5/055 (2006.01); A61B 6/50 (2024.01); A61K 31/573 (2006.01); A61K 51/12 (2006.01)
CPC A61B 6/037 (2013.01) [A61B 5/055 (2013.01); A61B 6/50 (2013.01); A61K 31/573 (2013.01); A61K 51/121 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of measuring endocochlear potential (EP) in a patient in need thereof comprising:
administering a therapeutically effective amount of at least one radiotracer to a patient;
performing nuclear imaging on cochlea of the patient;
measuring a level of radiation signals emitting from the at least one radiotracer wherein the level of the radiation signals are proportional to a level of potassium or sodium ion concentration in the cochlea of the patient; and
comparing the level of the potassium or the sodium ion concentration in the cochlea of the patient as measured by the radiation signals to a level of potassium or sodium ion concentration of a normal control;
wherein a decrease in the level of the potassium ion concentration or an increase in the level of the sodium ion concentration in the cochlea of the patient as measured by the radiation signals as compared to the level of the potassium ion concentration or the sodium ion concentration in the normal control indicates a decrease in EP.