| CPC A61B 5/725 (2013.01) [A61B 5/1116 (2013.01); A61B 5/352 (2021.01); A61B 5/355 (2021.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61B 2560/02 (2013.01)] | 20 Claims |

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1. A computer implemented method, comprising:
under control of one or more processors of an implantable medical device (IMD), where the one or more processors are configured with specific executable instructions to:
obtain motion data indicative of a first posture;
determine a first sense setting for cardiac activity (CA) signals sensed by at least one electrode of the IMD based on the first posture;
obtain, with the at least one electrode, CA signals for a series of beats while applying the first sense setting;
obtain a characteristic of interest (COI) from the CA signals for the series of beats;
periodically obtain additional cardiac signals;
in response to obtaining the additional cardiac signals, calculate with a self-learning algorithm, on a time dependent basis that includes a determined time period, a statistical indicator at the first posture from the COI over the series of beats based on the COI from the additional CA signals;
derive and implement a second sense setting for the additional CA signals sensed by the at least one electrode based on the first sense setting and the statistical indicator of the COI.
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