US 12,433,510 B2
Methods and systems for improved collection of interstitial fluid
Pradnya Samant, Atlanta, GA (US); Chandana Kolluru, Atlanta, GA (US); and Mark R. Prausnitz, Atlanta, GA (US)
Assigned to Georgia Tech Research Corporation, Atlanta, GA (US)
Appl. No. 16/955,681
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
PCT Filed Dec. 21, 2018, PCT No. PCT/US2018/067269
§ 371(c)(1), (2) Date Jun. 18, 2020,
PCT Pub. No. WO2019/126735, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/741,591, filed on Oct. 5, 2018.
Claims priority of provisional application 62/623,662, filed on Jan. 30, 2018.
Claims priority of provisional application 62/608,865, filed on Dec. 21, 2017.
Prior Publication US 2020/0315502 A1, Oct. 8, 2020
Int. Cl. A61B 5/145 (2006.01); A61B 5/15 (2006.01); A61B 10/00 (2006.01); A61M 37/00 (2006.01)
CPC A61B 5/14514 (2013.01) [A61B 10/0045 (2013.01); A61B 5/145 (2013.01); A61B 5/14507 (2013.01); A61B 5/1451 (2013.01); A61B 5/15 (2013.01); A61B 5/150015 (2013.01); A61B 2010/008 (2013.01); A61M 37/0015 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/003 (2013.01); A61M 2037/0038 (2013.01); A61M 2037/0046 (2013.01); A61M 2037/0061 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method for collecting interstitial fluid (ISF) from a patient's skin, the method comprising:
inserting a plurality of microneedles into the patient's skin at an insertion site to form a plurality of apertures in the patient's stratum corneum at the insertion site;
inducing local edema to mobilize ISF within the patient's dermis at the insertion site; and
collecting the ISF that flows from the apertures to a surface of the patient's skin at the insertion site,
wherein the inducing the local edema within the patient's dermis is effective to increase a rate and/or a total amount of the ISF flowing from the apertures.