US 12,433,480 B2
Methods, systems, and devices for vision testing
Ann E. Elsner, Bloomington, IN (US)
Assigned to The Trustees of Indiana University, Bloomington, IN (US)
Appl. No. 18/719,542
Filed by THE TRUSTEES OF INDIANA UNIVERSITY, Bloomington, IN (US)
PCT Filed May 3, 2022, PCT No. PCT/US2022/027284
§ 371(c)(1), (2) Date Jun. 13, 2024,
PCT Pub. No. WO2023/113854, PCT Pub. Date Jun. 22, 2023.
Prior Publication US 2024/0423466 A1, Dec. 26, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 3/10 (2006.01); A61B 3/00 (2006.01); A61B 3/028 (2006.01); A61B 3/14 (2006.01)
CPC A61B 3/1015 (2013.01) [A61B 3/0008 (2013.01); A61B 3/0025 (2013.01); A61B 3/028 (2013.01); A61B 3/101 (2013.01); A61B 3/1025 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A system to measure visual function of an eye having a pupil, while quantifying or minimizing factors that negatively affect vision but are unrelated to the status of the retina, comprising:
(a) a visual display that projects light through the pupil of the eye and onto the retina, and having an optical design capable of passing the majority of the light through the pupil to eliminate individual differences in the amount of light reaching the retina while transmitting a visual stimulus accurately including at high spatial frequencies or low contrast;
(b) a processor configured to receive, from a source that includes an imaging device or a database, data indicative of an image of an ocular fundus, wherein the image includes one or more retinal images including details based on a status of one or more of a retinal structure, a subretinal structure, or a locus of fixation;
(c) the processor configured to compare the visual stimulus from the visual display to the one or more retinal images to provide the locus of the target on the retina, known as the locus of fixation and in other fields as the preferred retinal locus;
(d) the processor configured to receive wavefront measurements to assess visual function being tested based on the deviations in the plane of the pupil of the eye of the wavefront for the light reaching the retina at the location of the visual stimulus;
(e) wherein the processor determines wavefront errors resulting from the optics of the eye from the wavefront measurements;
(f) a control mechanism to control one or more adaptive optics components to correct the wavefront errors of the visual display to achieve an improved focus of the visual stimulus on the retina;
(g) wherein the processor adjusts the focus of the visual stimulus on the retina based on the wavefront measurements and assesses corrected and uncorrectable wavefront aberrations;
(h) a response mechanism to record judgements about the visual stimulus;
(i) wherein the control mechanism controls one or more parameters of the visual stimulus of the visual wavelength display;
(j) wherein the processor computes the parameters to be used in the visual display or the final output, according to the results of b, c, d, e, g, h, and i;
(k) wherein the measurement of visual function includes the expectation for vision with successful retinal treatment or if elimination of unrelated factors such as lens opacities is achieved, and
(l) wherein the processor provides a measure of visual function metrics that includes a measure of central tendency and variability, and specify an upper bound that must be exceeded to conclude that retinal status is being improved, and the visual function metrics include a lower bound that must be exceeded to conclude that retinal status is not worsening.