US 12,108,128 B2
Apparatus, system and method to capture images of a medical site in white light and fluorescent light
Christin Baumann, Tuttlingen (DE)
Assigned to KARL STORZ SE & Co KG, Tuttlingen (DE)
Filed by KARL STORZ SE & Co KG, Tuttlingen (DE)
Filed on Dec. 10, 2021, as Appl. No. 17/547,844.
Claims priority of application No. 102020132951.2 (DE), filed on Dec. 10, 2020.
Prior Publication US 2022/0191439 A1, Jun. 16, 2022
Int. Cl. H04N 23/16 (2023.01); A61B 5/00 (2006.01); A61K 49/00 (2006.01); H04N 9/68 (2023.01); H04N 23/45 (2023.01); H04N 23/72 (2023.01)
CPC H04N 23/16 (2023.01) [A61B 5/0071 (2013.01); A61K 49/0021 (2013.01); A61K 49/0032 (2013.01); A61K 49/0034 (2013.01); A61K 49/0058 (2013.01); H04N 9/68 (2013.01); H04N 23/45 (2023.01); H04N 23/72 (2023.01)] 3 Claims
OG exemplary drawing
 
1. A method for capturing an image of an object of medical interest in remitted or reflected illumination light and capturing an image of the object in fluorescent light generated by at least one of Cy5.5 and SGM-101 and capturing an image of the object in fluorescence light generated by at least one of OTL38 and indocyanine green, comprising the steps of:
irradiating the object with illumination light in the blue, green and red spectral range;
irradiating the object with first excitation light exciting fluorescence of at least one of Cy5.5 and SGM-101;
irradiating the object with second excitation light exciting fluorescence of at least one of OTL38 and indocyanine green;
capturing a color image of the object in the blue, green and red spectral range by a first image sensor;
irradiating the object with illumination light in the blue, green and red spectral range or irradiating with red light in the red spectral range;
capturing a red light image of the object in the red spectral range by the second image sensor during irradiation of the object with illumination light in the blue, green and red spectral range or with red light in the red spectral range;
correcting the red color channel of the color image on the basis of the red light image; and
capturing a fluorescence image in the red and infrared spectral range, by a second image sensor,
wherein reflected or remitted first excitation light is not or only partially detected by the second image sensor, wherein reflected or remitted second excitation light is not or only partially detected by the second image sensor, and wherein the object is not irradiated with the second excitation light during capture of the red light image.