US 12,105,069 B2
Liquid sending system for liquid chromatograph
Tomohiro Gomi, Kyoto (JP); Daisuke Kitabayashi, Kyoto (JP); Shinya Imamura, Kyoto (JP); Keisuke Ogawa, Kyoto (JP); Masataka Nikko, Kyoto (JP); and Masahide Gunji, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/438,421
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed Oct. 16, 2019, PCT No. PCT/JP2019/040649
§ 371(c)(1), (2) Date Sep. 11, 2021,
PCT Pub. No. WO2020/183774, PCT Pub. Date Sep. 17, 2020.
Claims priority of application No. 2019-045544 (JP), filed on Mar. 13, 2019.
Prior Publication US 2022/0128533 A1, Apr. 28, 2022
Int. Cl. G01N 30/86 (2006.01); G01N 30/02 (2006.01); G01N 30/32 (2006.01)
CPC G01N 30/8658 (2013.01) [G01N 30/32 (2013.01); G01N 2030/027 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A liquid sending system for a liquid chromatograph comprising:
a liquid sending pump configured to consecutively send liquid using at least one plunger pump that sends liquid by reciprocally driving a plunger;
a pressure sensor for detecting a liquid sending pressure applied by the liquid sending pump; and
a liquid sending failure detector configured to acquire a liquid sending pressure detected by the pressure sensor periodically and detect a liquid sending failure of the liquid sending pump using the acquired liquid sending pressure by executing:
a pulsation detection step of:
obtaining a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending pump; and
detecting pulsation when the fluctuation range exceeds a predetermined reference value for a number of consecutive periods that exceeds a predetermined reference count; and
a liquid sending failure detection step of detecting a liquid sending failure of the liquid sending pump when the pulsation is detected in the pulsation detection step,
the liquid sending pump includes a first plunger pump and a second plunger pump that are driven complementarily, and
the liquid sending failure detector is configured to obtain a difference between the liquid sending pressures at a start point and an end point of a discharging operation of the first plunger pump as a first fluctuation value, obtain a difference between the liquid sending pressures at a start point and an end point of a discharging operation of the second plunger pump as a second fluctuation value, and obtain the fluctuation range using the first fluctuation value and the second fluctuation value.