US 12,105,066 B2
Preparative liquid chromatograph and analysis method
Yusuke Nagai, Kyoto (JP); and Yohei Toji, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Filed by SHIMADZU CORPORATION, Kyoto (JP)
Filed on Feb. 11, 2022, as Appl. No. 17/669,909.
Claims priority of application No. 2021-042393 (JP), filed on Mar. 16, 2021.
Prior Publication US 2022/0299485 A1, Sep. 22, 2022
Int. Cl. G01N 30/82 (2006.01); G01N 30/10 (2006.01); G01N 30/02 (2006.01); G01N 30/80 (2006.01)
CPC G01N 30/82 (2013.01) [G01N 30/10 (2013.01); G01N 2030/027 (2013.01); G01N 30/80 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A preparative liquid chromatograph comprising:
a liquid feeding pump that feeds a mobile phase;
an injector that injects a sample into the mobile phase at a downstream of the liquid feeding pump;
a separation column for separating components in the sample injected into the mobile phase by the injector at a downstream of the injector; and
an eluate fractionator configured to divide a flow of the eluate from the separation column into a first flow and a second flow having a larger flow rate than the first flow at a downstream of the separation column and to extract at least a part of an eluate that forms the first flow into a fractionation container, wherein:
the eluate fractionator has a first channel and a second channel that are branched from each other at the downstream of the separation column, the eluate that forms the first flow flows through the first channel, and eluate that forms the second flow flows through the second channel, and the eluate that has passed through the first channel is extracted by being dropped to the fractionation container,
the eluate fractionator is configured to collect the eluate that has passed through the second channel in a collection container,
the preparative liquid chromatograph includes a controller configured to extract a plurality of portions of the eluate that has passed through the first channel into the fractionation container by controlling an operation of the eluate fractionator and to separately collect portions each corresponding to each of the plurality of portions extracted into the fractionation container in the eluate that has passed through the second channel into the collection container different from each other,
a plurality of eluate holding parts for holding the eluate dropped from the eluate fractionator are arrayed in a planar manner in the fractionation container, and
the controller is configured to store a correspondence relationship between each of the eluate holding parts in which each of the plurality of portions extracted in the fractionation container is held and each collection container in which each portion corresponding to each of the plurality of portions in the eluate that has passed through the second channel is collected.