a bioreactor vessel;

an oxygen supply line;

a control valve that regulates a flow of oxygen through the oxygen supply line into the bioreactor vessel;

a biomass sensor configured to capture biomass measurement data characterizing biomass levels in the bioreactor vessel;

one or more computers; and

one or more storage devices communicatively coupled to the one or more computers, wherein the one or more storage devices store instructions that, when executed by the one or more computers, cause the one or more computers to perform operations comprising:

receiving, from the biomass sensor, current biomass measurement data characterizing current biomass levels in the bioreactor vessel;

processing the current biomass measurement data using a prediction model, in accordance with values of a set of model parameters, to generate data defining a predicted oxygen input amount required to maintain dissolved oxygen levels in the bioreactor vessel at a target dissolved oxygen level; and

controlling the control valve to cause the predicted oxygen input amount to flow through the oxygen supply line into the bioreactor vessel;

wherein the operations further comprise, prior to controlling the control valve to cause the predicted oxygen input amount to flow through the oxygen supply line into the bioreactor vessel:

determining that the control valve should be controlled based on the current biomass measurement data instead of current dissolved oxygen measurement data.