US 12,104,997 B2
Multi-axis specimen imaging device with embedded orientation markers
Donogh O'Driscoll, Tucson, AZ (US); Ciaran Purdy, Tucson, AZ (US); Kimberly A. Fitzpatrick, Tuscon, AZ (US); and Marisa H. Borders, Tucson, AZ (US)
Assigned to Faxitron Bioptics, LLC, Marlborough, MA (US)
Filed by Faxitron Bioptics, LLC, Marlborough, MA (US)
Filed on Dec. 15, 2022, as Appl. No. 18/081,923.
Application 18/081,923 is a continuation of application No. 16/932,008, filed on Jul. 17, 2020, granted, now 11,566,981.
Application 16/932,008 is a continuation of application No. 15/904,567, filed on Feb. 26, 2018, granted, now 10,753,836, issued on Aug. 25, 2020.
Application 15/904,567 is a continuation of application No. PCT/US2016/050169, filed on Sep. 2, 2016.
Claims priority of provisional application 62/215,064, filed on Sep. 7, 2015.
Claims priority of provisional application 62/214,520, filed on Sep. 4, 2015.
Prior Publication US 2023/0204473 A1, Jun. 29, 2023
Int. Cl. G06K 9/00 (2022.01); A61B 10/00 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); G01N 1/36 (2006.01); G01N 23/04 (2018.01); A61B 10/02 (2006.01)
CPC G01N 1/36 (2013.01) [A61B 10/0041 (2013.01); B01L 3/508 (2013.01); C12M 45/22 (2013.01); G01N 23/04 (2013.01); A61B 10/0233 (2013.01); B01L 2300/0609 (2013.01); G01N 2223/307 (2013.01); G01N 2223/6126 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method of imaging a tissue specimen, the method comprising:
providing a tissue specimen retaining apparatus having a body that includes a retention surface, a first orientation marker, a second orientation marker, and at least one indicator;
positioning the tissue specimen on the retention surface and relative to the at least one indicator such that the position of the tissue specimen on the retention surface corresponds to an excision location of the tissue specimen on a patient's breast, wherein the at least one indicator conveys a location of the first orientation marker;
generating a first image of the tissue specimen at an imaging system, wherein the tissue specimen retaining apparatus is orientated such that the retention surface is orthogonal to an imaging axis of the imaging system, wherein the first orientation marker, the second orientation marker, and the at least one indicator appear in the first image, and wherein the first orientation marker is spaced from the tissue specimen in the first image and indicates either a left breast or a right breast excision location and the second orientation marker is fully encompassed within the tissue specimen in the first image;
generating a second image of the tissue specimen at the imaging system, wherein the tissue specimen retaining apparatus is oriented such that the retention surface is not orthogonal to the imaging axis of the imaging system, wherein at least the first orientation marker and the second orientation marker appear in the second image, and wherein the first orientation marker is spaced from the tissue specimen in the second image and indicates either the left breast or the right breast excision location and the second orientation marker is also spaced from the tissue specimen in the second image and indicates an approximate location of a front or a nipple of the breast; and
determining, based on the position of the tissue specimen relative to the first orientation marker and the second orientation marker, the excision location of the tissue specimen on the patient's breast in the first image and the second image such that at least one of the first and second images are oriented relative to a corresponding original mammogram image.