a) is at least partially complementary to at least a portion of at least a first and a second mRNA originating from two genetic loci that are associated with a disease or condition;

b) is non-naturally encoded miR-30 miRNA;

c) comprises at least 90% sequence identity to a sequence selected from SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 624, SEQ ID NO: 625, SEQ ID NO: 626, SEQ ID NO: 627, SEQ ID NO: 629, SEQ ID NO: 630, SEQ ID NO: 632, SEQ ID NO: 633, SEQ ID NO: 635, SEQ ID NO: 636, SEQ ID NO: 637, SEQ ID NO: 638, SEQ ID NO: 639, SEQ ID NO: 640, SEQ ID NO: 641, SEQ ID NO: 642, and SEQ ID NO: 643, as determined by a BLAST pairwise sequence alignment algorithm;

d) comprises one or more nucleotide insertions, nucleotide deletions, nucleotide substitutions, or any combination thereof, relative to one or more otherwise comparable naturally encoded, mature miR-30 miRNA; and,

e) comprises about 10% lower Gibbs free energy (AG) of binding or lower, relative to a ΔG of binding of the otherwise comparable mature miR-30 miRNA binding to both the first and the second mRNA, wherein the bindings are at about 37 degrees Celsius and at a pH ranging from about 7.2 to about 7.6.