	US 12,103,960 B2
	VEGF traps and mini-traps and methods for treating ocular disorders and cancer
William Olson, Yorktown Heights, NY (US); Joel Martin, Putnam Valley, NY (US); Neil Stahl, Carmel, NY (US); and Jee Kim, Ardsley, NY (US)
Assigned to REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed on May 7, 2021, as Appl. No. 17/314,503.
Claims priority of provisional application 63/022,178, filed on May 8, 2020.
Prior Publication US 2021/0347852 A1, Nov. 11, 2021
Int. Cl. C07K 14/71 (2006.01); A61K 38/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 35/00 (2006.01)

CPC C07K 14/71 (2013.01) [A61P 27/02 (2018.01); A61K 38/00 (2013.01); C07K 2317/53 (2013.01)]

10 Claims

1. A vascular endothelial growth factor (VEGF) mini-trap which is a homodimer comprising two polypeptides wherein the amino acid sequence of each polypeptide consists of:

(SEQ ID NO: 33)
SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTL
IPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQT
NTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQH
KKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKN
STFVRVHEKVECPPCPAPPVA;
or

(SEQ ID NO: 116)
SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTL
IPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQT
NTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQH
KKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKN
STFVRVHEKVECPPCPAPPV.