US 12,103,944 B2
Compositions and methods for synthesizing 5′-capped RNAs
Richard I. Hogrefe, San Diego, CA (US); Alexandre Lebedev, San Diego, CA (US); Anton P. McCaffrey, San Diego, CA (US); and Dongwon Shin, San Diego, CA (US)
Assigned to TriLink BioTechnologies, LLC, San Diego, CA (US)
Filed by TriLink BioTechnologies, LLC, San Diego, CA (US)
Filed on Jan. 9, 2024, as Appl. No. 18/408,431.
Application 18/408,431 is a continuation of application No. 18/467,224, filed on Sep. 14, 2023.
Application 18/467,224 is a continuation of application No. 17/091,422, filed on Nov. 6, 2020, granted, now 11,878,991.
Application 17/091,422 is a continuation of application No. 15/761,957, granted, now 10,913,768, issued on Feb. 9, 2021, previously published as PCT/US2016/052670, filed on Sep. 20, 2016.
Claims priority of provisional application 62/221,248, filed on Sep. 21, 2015.
Prior Publication US 2024/0158433 A1, May 16, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 21/02 (2006.01); A23L 33/13 (2016.01); A61K 31/711 (2006.01); A61K 31/7115 (2006.01); A61K 31/712 (2006.01); C12N 15/11 (2006.01); C12P 19/34 (2006.01)
CPC C07H 21/02 (2013.01) [A23L 33/13 (2016.08); A61K 31/711 (2013.01); A61K 31/7115 (2013.01); A61K 31/712 (2013.01); C12N 15/11 (2013.01); C12P 19/34 (2013.01); C12Y 207/07 (2013.01)] 16 Claims
 
1. A compound of the following formula:

OG Complex Work Unit Chemistry
or a salt thereof, wherein:
B1 and B2 are each independently an unprotected nucleoside base;
R1 is CH3; and
R2 is H or CH3.