US 12,102,973 B2
Three-dimensional polymer networks with channels situated therein
Holger Klapproth, Freiburg (DE); and Sonja Bednar, Gundelfingen (DE)
Assigned to Safeguard Biosystems Holdings Ltd., London (GB)
Filed by SAFEGUARD BIOSYSTEMS HOLDINGS LTD., London (GB)
Filed on Jul. 15, 2022, as Appl. No. 17/866,080.
Application 17/866,080 is a continuation of application No. 16/062,761, granted, now 11,420,174, previously published as PCT/EP2016/081457, filed on Dec. 16, 2016.
Application 16/062,761 is a continuation in part of application No. 15/008,728, filed on Jan. 28, 2016, granted, now 9,738,926, issued on Aug. 22, 2017.
Claims priority of application No. 15201355 (EP), filed on Dec. 18, 2015.
Prior Publication US 2023/0141219 A1, May 11, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. B01J 19/00 (2006.01); C12Q 1/6837 (2018.01); C12Q 1/689 (2018.01)
CPC B01J 19/0046 (2013.01) [C12Q 1/6837 (2013.01); C12Q 1/689 (2013.01); B01J 2219/0061 (2013.01); B01J 2219/00626 (2013.01); B01J 2219/00644 (2013.01); B01J 2219/00664 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A three-dimensional network having a surface and an interior, said three-dimensional network:
(a) is composed of a water-swellable polymer of crosslinked water-soluble polymer chains;
(b) is crosslinked to the surface of a substrate;
(c) comprises multiple pluralities of channels, wherein:
(i) each plurality of channels comprises channels that converge at a point in the interior of the network such that the lateral distance between the channels decreases from the surface of the network toward the point in the interior; and
(ii) each plurality of channels converges at a different point in the three-dimensional network; and
(d) comprises probe molecules covalently attached to the polymer chains.