US 12,102,785 B2
Inner ear drug delivery devices and methods of use
Kevin W. Sacherman, South San Francisco, CA (US); Signe Erickson, South San Francisco, CA (US); Hugo Peris, South San Francisco, CA (US); and Eugene de Juan, Jr., South San Francisco, CA (US)
Assigned to Spiral Therapeutics Inc., South San Francisco, CA (US)
Filed by SPIRAL THERAPEUTICS, INC., South San Francisco, CA (US)
Filed on Feb. 9, 2022, as Appl. No. 17/668,090.
Application 17/668,090 is a continuation of application No. 16/388,159, filed on Apr. 18, 2019, granted, now 11,273,295.
Claims priority of provisional application 62/660,163, filed on Apr. 19, 2018.
Prior Publication US 2022/0249815 A1, Aug. 11, 2022
Int. Cl. A61M 31/00 (2006.01); A61M 37/00 (2006.01)
CPC A61M 31/002 (2013.01) [A61M 37/00 (2013.01); A61M 2205/04 (2013.01); A61M 2210/0662 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method of delivering a therapeutic fluid to a round window niche of a cochlea, comprising:
injecting a therapeutic fluid comprising dexamethasone into a proximal port of an elongate fillable body that is axially aligned with a central lumen of a distal delivery shaft extending from a distal end of the elongate fillable body while the elongate fillable body is positioned entirely external to a tympanic membrane of an ear, the distal delivery shaft having a smaller diameter than an outer diameter of the elongate fillable body and the central lumen of the distal delivery shaft being filled entirely by the therapeutic fluid, wherein the elongate fillable body has a longitudinal length extending from the proximal port to the distal end that is greater than a maximum lateral width of the elongate fillable body and that is smaller than a longitudinal length of the distal delivery shaft; and
after injection into the proximal port axially aligned with the central lumen of the distal delivery shaft extending from the distal end of the elongate fillable body, delivering the therapeutic fluid comprising dexamethasone from the distal end of the elongate fillable body and through the distal delivery shaft that is positioned through the tympanic membrane and to a distal-most outlet adjacent to a round window niche of a cochlea such that about 5 μL to about 500 μL of the therapeutic fluid comprising dexamethasone is deposited into the round window niche, wherein the therapeutic fluid comprising dexamethasone deposited into the round window niche comprises a gel composition for sustained release of the dexamethasone.