US 12,102,733 B2
Pre-loadable biological heart valve capable of rapid rehydration and preparation method thereof
Yunbing Wang, Chengdu (CN); Gaocan Li, Chengdu (CN); Yang Lei, Chengdu (CN); Li Yang, Chengdu (CN); Hou-Sen Lim, Singapore (SG); Dajun Kuang, Zhejiang (CN); and Jincheng Yu, Hangzhou (CN)
Assigned to VENUS MEDTECH (HANGZHOU), INC., Hangzhou (CN); and Sichuan University, Chengdu (CN)
Filed by VENUS MEDTECH (HANGZHOU), INC., Zhejiang (CN); and Sichuan University, Chengdu (CN)
Filed on May 6, 2021, as Appl. No. 17/313,910.
Application 17/313,910 is a continuation of application No. PCT/CN2019/105371, filed on Sep. 11, 2019.
Prior Publication US 2021/0268151 A1, Sep. 2, 2021
Int. Cl. A61L 27/36 (2006.01)
CPC A61L 27/3687 (2013.01) [A61L 2300/214 (2013.01); A61L 2430/20 (2013.01); A61L 2430/40 (2013.01)] 20 Claims
 
1. A method for preparing a pre-loadable biological heart valve capable of rapid rehydration, comprising:
performing a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution;
performing a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and
performing a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain the pre-loadable biological heart valve capable of rapid rehydration;
wherein the cross-linking treatment is performed and completed first, then the hydrophilic treatment is performed, and finally the drying treatment is performed; or, the hydrophilic treatment is performed and completed first, then the cross-linking treatment is performed, and finally the drying treatment is performed.