US 12,102,692 B2
Materials and methods for delivering nucleic acids to cochlear and vestibular cells
Konstantina Stankovic, Boston, MA (US); Luk H. Vandenberghe, Weston, MA (US); Jeffrey Holt, Newton, MA (US); and Gwenaelle Geleoc, Newtonr, MA (US)
Assigned to Massachusetts Eye and Ear Infirmary, Boston, MA (US); Schepens Eye Research Institute, Boston, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Filed by Massachusetts Eye and Ear Infirmary, Boston, MA (US); The Schepens Eye Research Institute, Inc., Boston, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Filed on Oct. 5, 2021, as Appl. No. 17/450,008.
Application 17/450,008 is a continuation of application No. 16/060,841, granted, now 11,167,042, previously published as PCT/US2016/066225, filed on Dec. 12, 2016.
Claims priority of provisional application 62/266,462, filed on Dec. 11, 2015.
Claims priority of provisional application 62/266,477, filed on Dec. 11, 2015.
Prior Publication US 2022/0016262 A1, Jan. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); A61K 9/00 (2006.01); A61K 48/00 (2006.01); A61N 1/32 (2006.01); C07K 14/005 (2006.01); C12N 15/86 (2006.01)
CPC A61K 48/005 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 39/00 (2013.01); A61N 1/32 (2013.01); C07K 14/005 (2013.01); C12N 15/86 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01)] 28 Claims
 
1. An adeno-associated virus (AAV) vector comprising an Anc80 capsid protein and a transgene comprising ACTG1, ADCY1, ATOHI, ATP6V1B1, BDNF, BDP1, BSND, DATSPER2, CABP2, CD164, CDC14A, CEACAM16, CHD7, CCDC50, CLDN14, CLIC5, CLPP, COCH, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A2, COL11A1, COL11A2, CRYM, DCDC2, DFNA5, DFNB31, DFNB59, DIAPH1, EDN3, EDNRB, ELMOD3, EMOD3, EPS8, EPS8L2, ESPN, ESRRB, EYA1, EYA4, FAM65B, FOXII, GIPC3, GJB2, GJB3, GJB6, GPR98, GRHL2, GPSM2, GRXCR1, GRXCR2, HARS2, HGF, HOMER2, HSD17B4, ILDR1, KARS, KCNE1, KCNJ10, KCNQ1, KCNQ4, KITLG, LARS2, LHFPL5, LOXHD1, LRTOMT, MARVELD2, MCM2, MET, MIR183, MIRN96, MITF, MSRB3, MT-RNR1, MT-TS1, MYH14, MYH9, MYO15A, MYO1A, MY03A, MY06, NARS2, NDP,NF2, NT3, OSBPL2, OTOA, OTOF, OTOG, OTOGL, P2RX2, PAX3, PJVK, PNPT1, POLRID, POLRIC, POU3F4, POU4F3, PRPS1, PTPRQ, RDX, SIPR2, SEMA3E, SERPINB6, SLC17A8, SLC22A4, SLC26A4, SLC26A5, SIX1, SIX5, SMAC/DIABLO, SNAI2, SOX10, STRC, SYNE4, TBC1D24, TCOF1, TECTA, TIMM8A, TJP2, TNC, TMIE, TMEM132E, TMPRSS3, TRPN, TRIOBP, TSPEAR, USHIC, USHIG, USH2D, WFS1, or XIAP.