	US 12,102,688 B2
	Immunomodulatory nanofilaments
Carl Figdor, Nijmegen (NL); Roel Hammink, Nijmegen (NL); and Loek Eggermont, Nijmegen (NL)
Assigned to STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM, Nijmegen (NL)
Appl. No. 16/967,509
Filed by STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM, Nijmegen (NL)
PCT Filed Feb. 6, 2019, PCT No. PCT/EP2019/052922 § 371(c)(1), (2) Date Aug. 5, 2020, PCT Pub. No. WO2019/154865, PCT Pub. Date Aug. 15, 2019.
Claims priority of application No. 1801902 (GB), filed on Feb. 6, 2018.
Prior Publication US 2022/0401570 A1, Dec. 22, 2022
Int. Cl. A61K 47/68 (2017.01)

CPC A61K 47/6813 (2017.08) [A61K 47/6849 (2017.08); A61K 47/6883 (2017.08)]

17 Claims

1. A polyisocyanopeptide (PIC) nanofilament comprising a plurality of molecules of a first cytokine attached to a PIC backbone, wherein the cytokine is IL-2 or IFNα, and further comprising a plurality of molecules of a binding molecule attached to the PIC backbone, wherein the binding molecule binds to a molecule presented by a T cell.