	US 12,102,682 B1
	Injectable photothermal hydrogel based on melanin, preparation method, and application thereof
Jing Chang, Qingdao (CN); Lili Guo, Qingdao (CN); Lan Guo, Qingdao (CN); Jishang Sun, Qingdao (CN); Cuiyao Li, Qingdao (CN); and Baoqin Han, Qingdao (CN)
Assigned to OCEAN UNIVERSITY OF CHINA, Qingdao (CN)
Filed by OCEAN UNIVERSITY OF CHINA, Shandong (CN)
Filed on Mar. 1, 2024, as Appl. No. 18/593,842.
Claims priority of application No. 202310904416.5 (CN), filed on Jul. 21, 2023.
Int. Cl. A61K 41/00 (2020.01); A61K 9/00 (2006.01); A61K 31/704 (2006.01); A61K 47/10 (2017.01); A61K 47/22 (2006.01); A61K 47/36 (2006.01)

CPC A61K 41/0057 (2013.01) [A61K 9/0019 (2013.01); A61K 31/704 (2013.01); A61K 47/10 (2013.01); A61K 47/22 (2013.01); A61K 47/36 (2013.01)]

6 Claims

1. An injectable photothermal hydrogel based on melanin, wherein the injectable photothermal hydrogel is a hydroxypropyl chitosan/bis-amino polyethylene glycol modified melanin nanoparticles (HPCS/MP) hydrogel, the HPCS/MP hydrogel is prepared by mixing bis-amino polyethylene glycol modified melanin nanoparticles (MP) with hydroxypropyl chitosan (HPCS); the MP is synthesized by an amidation reaction of melanin and bis-amino PEG; a ratio of a volume of an MP solution to a volume of an HPCS solution in the HPCS/MP hydrogel is 4:6; and a concentration of the MP solution is 20 wt %, and a concentration of the HPCS solution is 4 wt %.